The study, “Glucose-sensing pulmonary delivery of human insulin to the systemic circulation of rats,” was conducted in the laboratory of Ananth V. Annapragada, Ph.D., an associate professor at the UT School of Health Information Sciences. Research assistant Efstathios Karathanasis was lead author and postdoctoral fellow Rohan C. Bhavane was a contributor on the article.
The smart particle system consists of a blood sugar sensing protein named concanavalin A (Con A) and bundles of tiny fat bubbles called liposomes that are loaded with insulin. “Con A binds insulin-containing liposomes that are coated with sugars, to each other, to form the inhaled particles,” Annapragada said. “When blood sugar becomes present, the Con A releases the particles to bind independently to the sugars. The released particles then release their insulin.”
The smart particle system could potentially treat other health conditions, he said.
The article in the International Journal of Nanomedicine is available online at:
dovepress.com/ Smart particle research is supported by the Whitaker Foundation Bioengineering Research Grant and the Gillson-Longenbaugh Foundation.
Contact: Rob Cahill Robert.Cahill@uth.tmc.edu 713-500-3030 University of Texas Health Science Center at Houston
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